METHOD OF PRODUCTION OF NUCLEOSIDE PHOSPHORYLASE AND NUCLEOSIDASE INHIBITORS Russian patent published in 2008 - IPC C07H19/23 A61K31/7076 A61P31/04 A61P33/02 A61P35/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention can be applied in medicine and refers to method of production of compounds by formula (I) which are inhibitors of purine nucleoside phosphorylases, purine phosphoribosile transferases, 5'-methylthioadenosine phosphorylases, 5'- methylthioadenosine nucleosidases and nucleoside hydrolases. (I) where V and X represent CH₂; Y represents H; Z represents phenyl, phenylthio, phenoxy, alkyl, alkylthio, alkyloxy, optionally substituted, or H, halogen, OH, escaping sulphonate group; W represents NR¹; R¹ represents radical of formula (II) where A represents CH; B is selected from OH, NH₂, Nh-alkyl, SH and halogen; D represents H or NH₂; E represents N.

EFFECT: development of new production methods of biologically active compounds.

4 cl, 42 ex, 1 tbl