FIELD: medicine; oncology; molecular biology.
SUBSTANCE: to diagnose non-small cell lung carcinoma potentially cancer-affected human tissue and adjacent histologically normal tissue are tested for gene WIF1 transcription level. Lowered transcription level detected in potentially cancer-affected human tissue compared to that of adjacent histologically normal tissue is diagnostic indicator of non-small cell lung carcinoma. For realisation of polymerase chain reaction within detection of gene WIF1 transcription level, primers set of sequence SEQ ID NO: 1 and 2 is used.
EFFECT: invention application provides high-reliable diagnostics of non-small cell lung carcinoma, including squamous cell carcinoma, as well as at earliest stage of tumour transformation progression.
8 cl, 2 dwg, 1 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIAGNOSING TECHNIQUE FOR NON-SMALL-CELL LUNG CANCER AND SET FOR IMPLEMENTING THEREOF | 2010 |
|
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| METHOD OF EPIDERMOID LUNG CANCER DIAGNOSTICS AND RELATED SET | 2006 |
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| DIAGNOSTIC TECHNIQUE FOR NON-SMALL CELL CARCINOMA OF LUNG AND KIT FOR IMPLEMENTATION THEREOF | 2008 |
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| METHOD OF DIAGNOSING SQUAMOUS CELL CARCINOMA OF LUNG AND KIT FOR IMPLEMENTATION THEREOF | 2014 |
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| DETERMINING mRNA LEVEL REDUCTION IN GENES ITGA9, HYAL1 AND HYAL2 AS METHOD OF DIAGNOSING NON-SMALL CELL LUNG CANCER AND SET FOR ITS REALISATION | 2008 |
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| DIAGNOSTIC TECHNIQUE FOR CLEAR CELL RENAL ADENOCARCINOMA AND SET FOR IMPLEMENTATION THEREOF | 2009 |
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| METHOD FOR DETERMINING NON-SMALL CELLS LUNG CANCER SENSITIVITY TO PREPARATIONS REACTIVATING PROTEIN p53 | 2012 |
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| DIAGNOSTIC TECHNIQUE FOR COLON CANCER AND KIT FOR IMPLEMENTING THEREOF | 2008 |
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