FIELD: medicine.
SUBSTANCE: invention refers to oncology and molecular biology. What is presented is a method for determining the non-small cells lung cancer sensitivity to the preparations reactivating protein p53, involving the recovery of RNA from samples, the synthesis of complementary DNA of the genes CDKN1A, BTG2 and E2F1 by reverse transcription and real-time polymerase chain reaction, and the determination of a relation of the amount of complementary DNA of the gene E2F1 to the amount of complementary DNA of the gene CDKN1A or the gene BTG2, wherein if observing the relation of E2F1/CDKN1A>3 or E2F1/BTG2>1.5, the non-small cells lung cancer cells are considered to be sensitive to the preparations reactivating protein p53.
EFFECT: invention may be used in treating oncological diseases.
3 dwg, 3 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DETECTING TRANSCRIPTION LEVEL OF GENE CODING HUMAN CHEMOKINE CCL2 (MCP-1) AND KIT FOR IMPLEMENTING IT | 2012 |
|
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| TREATMENT OF TUMORS WITH A COMBINATION OF ONCOLYTIC ADENOVIRUS AND CDK4/6 INHIBITOR | 2019 |
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| DIAGNOSING TECHNIQUE FOR NON-SMALL-CELL LUNG CANCER AND SET FOR IMPLEMENTING THEREOF | 2010 |
|
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| METHOD OF EPIDERMOID LUNG CANCER DIAGNOSTICS AND RELATED SET | 2006 |
|
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| METHOD OF NON-SMALL CELL LUNG CARCINOMA DIAGNOSTICS AND RELATED ANALYSIS SET | 2006 |
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| METHOD OF DIAGNOSING SQUAMOUS CELL CARCINOMA OF LUNG AND KIT FOR IMPLEMENTATION THEREOF | 2014 |
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| METHOD OF DIAGNOSING NON-SMALL CELL LUNG CANCER AND SET FOR REALISING IT | 2007 |
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RU2351936C1 |
