DIARYLCYCLOALKYL DERIVATIVES, METHOD OF THEIR OBTAINING, AND APPLICATION AS PPAR-ACTIVATORS Russian patent published in 2008 - IPC C07D263/32 C07D413/12 A61K31/421 A61K31/422 

FIELD: chemistry.

SUBSTANCE: invention concerns a compound of the formula (I) where A ring is (C₃-C₈)-cycloalkyl or (C₃-C₈)-cycloalkenyl where two carbon atoms in the cycloalkyl ring can be substituted by oxygen atoms; R1, R2 are H, F, Cl, Br, OH, CF₃, OCF₃, (C₁-C₆)-alkyl or O-(C₁-C₆)-alkyl independently from each other; R3 is H or (C₁-C₆)-alkyl; R4, R5 are H, (C₁-C₆)-alkyl independently from each other; X is (C₁-C₆)-alkyl where one carbon atom in the alkyl group can be substituted by oxygen atom; Y is (C₁-C₆)-alkyl where one carbon atom in the alkyl group can be substituted by oxygen atom; and its pharmaceutically acceptable salts. The invention also concerns such compounds as (+)-cis-2-(3-(2-(4-fluorphenyl)oxazole-4-ylmethoxy)cyclohexyloxymethyl)-6-methylbenzoic acid of the formula 6b , 2-{3-[2-(3-methoxyphenyl)-5-methyloxazole-4-ylmethoxy]cyclohexyl-oxymethyl}-6-methylbenzoic acid of the formula 53 and 2-methyl-6-[3-(5-methyl-2-n-tolyloxazole-4-ylmethoxy)cyclohexylomethyl]benzoic acid of the formula 70 , or their enantiomers. The invention also concerns pharmaceutical composition exhibiting PPARα agonist effect, including one or more compounds of the formula (I) as an active component together with a pharmaceutically acceptable carrier. The pharmaceutical composition is obtained by mixing of active compound of the formula (I) with a pharmaceutically acceptable carrier and rendering it a form viable for introduction.

EFFECT: obtaining of diarylcycloalkyl derivatives applicable as PPAR-activators.

9 cl, 2 tbl, 67 ex