SUBSTITUTED BENZOXAZOLES AND THEIR ANALOGUES AS OESTROGEN AGENTS Russian patent published in 2008 - IPC C07D263/57 C07D277/66 C07D235/18 A61K31/4184 A61K31/423 A61K31/428 A61P5/30 

Abstract RU 2330847 C2

FIELD: chemistry.

SUBSTANCE: invention concerns oestrogen receptor modulators of the formula (II) with the structure where R1 is an alkenyl of 2-7 carbon atoms with alkenyl group optionally substituted by -CN or halogen; R2 and R2a are hydrogen or halogen independently of each other; R3 and R3a are hydrogen or halogen independently of each other; X is O; or their pharmaceutically acceptable salts. The invention also concerns a method of obtaining the claimed compounds, pharmaceutical composition, and treatment methods for various diseases.

EFFECT: obtaining of the claimed compounds.

39 cl, 23 tbl, 98 ex

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RU 2 330 847 C2

Authors

Malamas Majkl Sotirios

Makdevitt Robert Ehmmett

Gunavan Ivan

Manas Ehrik Stiven

Kollini Majkl Dehvid

Kharris Khiter Ehnn

Kejt Dzhejms Karl Ml.

Ehlbert Leo Massillamani

Littl Sesil Richard

Dates

2008-08-10Published

2002-12-03Filed