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2 314 283

(13)

(51)

IPC

C07C39/38(2006-01-01)

A61K31/55(2006-01-01)

A61P5/30(2006-01-01)

A61P5/32(2006-01-01)

(21) (22)

Application

2004121227/04, 2002-12-12

(24)

Start date

2002-12-12

(22)

Actual filing date

2002-12-12

(45)

Published

2008-01-10

(72)

Inventor

M'Jusho Richard EhrikEhdsoll Richard DzhejmsJang KuidzianKharris Khiter EhnnKejt Dzhejms Karl Ml.Ehlbert Leo MassillamaniManas Ehrik Stiven

(73)

Holder

Uajt

SUBSTITUTED PHENYLNAPHTHALENES AS ESTROGENIC AGENTS Russian patent published in 2008 - IPC C07C39/38 A61K31/55 A61P5/30 A61P5/32

Abstract RU 2314283 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to modulators of estrogen receptors of the formula (I): wherein each R₁ and R₂ is chosen independently from hydrogen or halogen atom; each R₅, R₆, R₇, R₈ and R₉ represents independently hydrogen, halogen atom or -CN group under condition that at least one radical among R₅ or R₉ doesn't means hydrogen atom, or to their pharmaceutically acceptable salts. Also, invention relates to a method for synthesis of claimed compounds, a pharmaceutical composition and using compound of the formula (I) for producing a medicinal agent possessing activity of agonist or antagonist of estrogen receptor, and to methods for treatment or inhibition of different diseases.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

20 cl, 15 sch, 14 tbl, 55 ex

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RU 2 314 283 C2

Authors

M'Jusho Richard Ehrik

Ehdsoll Richard Dzhejms

Jang Kuidzian

Kharris Khiter Ehnn

Kejt Dzhejms Karl Ml.

Ehlbert Leo Massillamani

Manas Ehrik Stiven

Dates

2008-01-10—Published

2002-12-12—Filed