MARROW STROMAL CELL MATERIAL FOR APPLICATION IN BLOOD VESSEL FORMATION AND GENERATION OF ANGIOGENETIC AND TROPHIC FACTORS Russian patent published in 2008 - IPC A61K35/38 C12N5/06 C12N5/08 A61P25/00 A61P21/00 

FIELD: medicine.

SUBSTANCE: group of inventions concerns therapeutic angiogenesis stimulation and generation of trophic and angiogenetic factors, and can be applied in amplification of brain compensation mechanism for functional salvage after central neural system damage or degeneration. The invention claims: a therapeutic medium of angiogenesis and vasculogenesis inducing factors for application in neurological and musculoskeletal therapy, containing angiogenesis and vasculogenesis inducing factors detached from human marrow stem cells in combination with pharmaceutically acceptable therapeutic cell medium; generation amplification method for angiogenesis and vasculogenesis inducing factors released by stem cells involving exposure and joint cultivation of stem cells with a compound for generation improvement of angiogenesis and vasculogenesis inducing factors; angiogenesis and vasculogenesis inducing factors isolated and separated of stem cells for application in therapy; process of obtaining the claimed angiogenesis and vasculogenesis inducing factors, including stages of human mesenchymal stem cell isolation and separation from tissue, differentiation and further cultural cultivation of mesenchymal stem cells for obtaining of neurological and musculoskeletal therapeutic media; mesenchymal stem cells isolated and cultivated in a culture, capable of differentiation and generation of target cell phenotype for tissue recovery under the effect of a required compound.

EFFECT: improved efficiency of cellular therapy.

17 cl, 3 ex, 4 tbl, 9 dwg