IMIDAZOLE DERIVATIVES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION ON THEIR BASIS, THEIR USE AS PERIPHERICALLY SELECTIVE INHIBITORS DOPHAMINE-BETA-HYDROLAZE AND INTERMEDIATE COMPOUNDS Russian patent published in 2008 - IPC C07D405/04 C07D409/04 C07D233/84 A61K31/4164 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the compound of formula I: , where R₁, R₂ and R₃ are equal or different and represent hydrogen, halogen, alkyl, aloxy, hydroxyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group, R₄ represents hydrogen, alkyl or alkylaryl group; X represents CH_2, oxygen atom and sulphur atom; n represents 2 or 3, and individual (R)- and (S)-enantiomers or the mixture of enantiomers and its pharmaceutically acceptable salts; where alkyl termine denotes straight and branched hydrocarbon chains, containing fro one to six atoms of carbon, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups, termine aryl denotes phenyl or naphtyl group, optionally substituted alkyloxy group, halogen or nitro group, termine halogen denotes fluorine, chlorine, bromine or iodine. The compounds have valuable pharmaceutical properties and perspectives for the treatment of cardiovascular disorder, such as hypertension and chronic heart failure. The method of production of individual (R)- and (S)-enantiomers or the mixture of enantiomers and pharmaceutically acceptable salts of the compound of formula I, pharmaceutical composition having inhibitor dophamine-β-hydrolaze potency, containing therapeutic effective volume of the compound of formula I, different variants of formula I compound application and intermediate compounds are described.

EFFECT: production of new compounds, imidazole derivatives having useful biological properties.

21 cl, 2 tbl, 46 ex