AMINO-SUBSTITUTED ETHYLAMINO-AGONISTS OF β-ADRENERGIC RECEPTORS Russian patent published in 2010 - IPC C07C233/43 C07D215/24 A61K31/167 A61K31/4704 A61P11/08 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula (II) and their pharmaceutically acceptable salts and stereoisomers as β₂-adrenergic receptor agonists, to a pharmaceutical composition based on the said compounds, a treatment method, to a method of producing said compounds, their use, as well as to crystalline hydrochloride of N-[5-((R)-2-{2-[4-((R)-2-amino-2-phenylethylamino)phenyl]ethylamino}-1-hydroxyethyl)-2-hydroxyphenyl]formamide. The compounds can be used for treating and preventing β₂-adrenergic receptor mediated diseases such as asthma and chronic obstructive pulmonary disease. In general formula (II) , R¹ is NHCHO, and R² is hydrogen; or R¹ and R², taken together, represent -NHC(=O)CH=CH- or -CH=CHC(=O)NH-; each of R⁵ and R⁶ is independently selected from hydrogen or C_1-6-alkyl.

EFFECT: improved method.

14 cl, 3 dwg, 12 ex