NEW COMPOUNDS Russian patent published in 2008 - IPC C07D495/04 A61K31/519 A61P37/02 

FIELD: chemistry, pharmaceuticals.

SUBSTANCE: invention pertains to thienopyridazinones with formula , where R¹ represents C_1-6alkyl, or C_3-6cycloalkyl, R² represents C_1-6alkyl; R³ represents a CO-G group, where G is a 5-member ring, containing a nitrogen atom and a second heteroatom, chosen from oxygen, adjacent to the nitrogen atom, and can be substituted with groups in quantity of up to 2, chosen from hydroxyl and C_1-4alkyl; Q represents CR⁵R⁶, where R⁵ and R⁶ - hydrogen, and R⁴ represents a 5-10-member mono- or bi-cyclic aromatic ring system, containing 2 heteroatoms, independently chosen from nitrogen. This ring system can be substituted. The invention also relates to pharmaceutical salts and solvates of thienopyridazinones. Description is also given of the method of obtaining these compounds, pharmaceutical compositions containing them, and their use in therapy, particularly in the modulation of autoimmune disease.

EFFECT: obtaining thienopyridazinones for use in modulation of autoimmune disease.

12 cl, 17 ex