VECTOR ENABLING SARS VIRUS ANTIGEN EXPRESSION AT CELL SURFACE, AND MICROBES TRANSFORMED BY THIS VECTOR Russian patent published in 2008 - IPC C12N15/63 C12N15/33 C12N1/21 A61K39/12 

FIELD: biotechnologies.

SUBSTANCE: invention claims a vector including one, two or more pgsB, pgsC and pgsA genes encoding poly-gamma-glutamine acid synthase complex, and a gene encoding spike antigen albumen or antigen albumen of SARS coronavirus nucleocapsid. The gene encoding spike or SARS coronavirus nucleocapsid antigen albumen is linked to the C-end part of one, two or more pgsB, pgsC and pgsA genes. The vector enables albumen expression at a cell surface. Also the invention claims a microbe transformed by such vector enabling albumen expression at a cell surface, and a SARS preventing vaccine containing such microbe. The vaccine for SARS prevention and treatment, using recombinant strain expressing SARS coronavirus antigen over its surface, is efficient and cost-effective.

EFFECT: vector enabling albumen expression at a cell surface.

19 cl, 18 dwg, 9 ex