BENZAMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS OF SAID DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THERE ON AND APPLICATION THEREOF Russian patent published in 2008 - IPC C07C237/40 C07D295/14 C07D401/12 C07D401/14 C07D417/12 C07D417/14 C07D277/68 C07D413/12 A61K31/167 A61K31/4453 A61K31/4709 A61K31/428 A61K31/454 A61K31/538 A61K31/496 A61P1/04 A61P11/06 A61P13/10 A61P17/04 A61P25/06 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention concerns new compounds of the formula (I) and their pharmaceutically acceptable salts. The compounds claimed by the invention have inhibition effect on VR1 receptor activation and can be applied in pain prevention or treatment. In the general formula (I) , or , L is a low alkylene, E cycle is benzene or 5-membered heteroaromatic ring containing sulfur atom as a heteroatom, D cycle is a monocyclic or bicyclic hydrocarbon cycle optionally condensed with C_5-7 cycloalkyl, 6-membered monocyclic heteroaromatic cycle containing nitrogen atom as heteroatom or 9-11-membered bicyclic heteroaromatic cycle containing 1 to 3 equal or different heteroatoms selected out of the group including N, S and O, G cycle is a 5-7-membered monocyclic saturated or partially saturated heterocycle or 10-membered bicyclic heterocycle containing 1 to 3 equal or different heteroatoms selected out of the group including N, S and O. The invention also concerns pharmaceutical composition based on the said compounds, and application thereof in obtaining pain prevention or treatment medication, and a method of pain prevention or treatment.

EFFECT: obtaining prevention or treatment medium against pain.

24 cl, 470 ex, 41 tbl