DERIVATIVES OF SULFONAMIDES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to new derivatives of sulfonamides of the formula (I) or their pharmaceutically acceptable salts wherein R¹ means -OH or -NHOH; R² means hydrogen atom; R³ means alkyl, alkoxyalkyl, arylalkyl, pyridylalkyl or morpholinylalkyl; A means piperidyl or tetrahydrofuranyl; n = 0; E means a covalent bond; (C₁-C₄)-alkylene, -C(=O)-, -C(=O)O- or -SO₂-; X means hydrogen atom, alkyl, aryl, arylalkyl, alkoxyalkyl, morpholinyl or tetrahydropyranyl; each among G and G' means -C(R⁵)=C(R^5') wherein R⁵ and R^5' mean hydrogen atom; M means the group -CH-; z means the group -(CR⁷R^7')_a-L-R⁸ wherein a = 0 and each among R⁷ and R^7' means hydrogen atom; L means a covalent bond; R⁸ means halogen atom or alkoxy-group. Compounds of the formula (I) are inhibitors of metalloproteases and can be used for treatment of arthritis, cancer tumors and other diseases.

EFFECT: valuable medicinal properties of compounds.

15 cl, 7 tbl, 56 ex