FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof [Chemical formula 1]
,
where [Chemical formula 2]
is 
, 
or 
Y1 and Y2, each independently represent N(RY) or O; Z1 is C(R4) or N; Z2a is C(R5a) or N; Z2b is C(R5a) (R5a') or N(R5b); Z2c is C(R5a) or N; Z3a is C(R6) or N; provided that when Z1 is N, then each of Z2a, Z2b and Z2c is C(R5a); when Z1 is C(R4), then Z2c is N; and when Z2a is N, then Z3a is C(R6); RY, each independently represents a hydrogen atom, hydroxy, cyano, unsubstituted alkyl, unsubstituted alkyloxy; R4 and R6, each independently represent a hydrogen atom, halogen, substituted or unsubstituted alkyl, where substitutes are selected from alkyloxy; R5a and R5a', each independently represent a hydrogen atom, halogen, carboxy, carbamoyl, cyano, substituted or unsubstituted alkyl, where substitutes are selected from alkyloxy and hydroxy, unsubstituted alkyloxy; R5b is unsubstituted alkyl; R1 is phenyl substituted with one or more halogen atoms and optionally substituted with one or more identical or different substitutes selected from alkyl, haloalkyl, alkyloxy; R2a, each independently represents a hydrogen atom; R2b, each independently represents a hydrogen atom; X is N(R7a); R7a is a hydrogen atom; R2c, each independently represents a hydrogen atom; R2d, each independently represents a hydrogen atom; R3 represents a group represented by formula [Chemical formula 3]
, 
,
where Ring B is benzene or pyridine; Ring C is cyclopentane; n is equal to 1; m is integer from 0 to 1; p1 is integer from 0 to 2; p2 is equal to 1 (values of other radicals are presented in claim 1).
EFFECT: compounds have P2X7 receptor antagonist activity.
24 cl, 250 tbl, 36 ex
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