FIELD: medicine.
SUBSTANCE: invention claims a method of T-cell epitop chartering for a given albumen or its fragment by using peripheral blood mononuclear cells (PBMC). The invention also concerns T-cell epitop identification in therapeutic albumens. In addition, the invention concerns a combined approach to application of epitop chartering according to identification of MHC class II ligands detected by the claimed chartering method, and construction of similar sequence with less amount of such ligands.
EFFECT: screening methods for albumen molecule determinants and epitops identification.
17 cl, 3 dwg, 3 tbl, 5 ex
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