FIELD: physics.
SUBSTANCE: invention is related to analytical method. Device includes substrate with plasmon-resonance surface, on which sample is placed, source of light beam, and lens unit that has tip and nanolens installed on the tip, which consists of one or several plasmon-resonance particles (PRP). PRP are installed so that modes of electromagnet clearance are created in near-field region in the space between nanolens and detection area on substrate surface adjacent to it, with value of clearance between nanolens and substrate of 30 nm or less. Focusing mechanism in device executes displacement of lens beam in direction to substrate surface and back for creation of electromagnet clearance modes, which amplify spectral signal of combination dispersion that are generated by sample on detection area. Device and method are suitable, for instance, for identification of serially installed bases in single-stranded DNA, for direct sequencing of DNA.
EFFECT: provides possibility to to carry out parallel analysis of multiple samples.
18 cl, 8 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD AND DEVICE FOR IMPROVED NANOSPECTROSCOPIC SCANNING | 2005 |
|
RU2378627C2 |
| OPTICAL SENSOR WITH MULTILAYERED PLASMON STRUCTURE FOR IMPROVED DETECTION OF CHEMICAL GROUPS THROUGH SERS | 2005 |
|
RU2361193C2 |
| DIMERIC OCCLUDANT NANOSTRUCTURE, LABELLED WITH MOLECULE, ACTIVE WITH RESPECT TO RAMAN SCATTERING, LOCATED IN INTER-PARTICLE COMPOUND, APPLICATION AND METHOD OF OBTAINING THEREOF | 2010 |
|
RU2542386C2 |
| PLANAR NANOSTRUCTURED SENSOR BASED ON SURFACE PLASMON RESONANCE TO ENHANCE RAMAN LIGHT SCATTERING OF HUMAN PLATELETS AND METHOD FOR ITS PRODUCTION | 2022 |
|
RU2788479C1 |
| METHOD OF PRODUCING AMPLIFIED SIGNAL OF RAMAN LIGHT SCATTERING FROM HUMAN SERUM ALBUMIN MOLECULES IN LIQUID DROPLET | 2019 |
|
RU2708546C1 |
| OPTICAL SENSOR WITH A PLASMON STRUCTURE FOR DETERMINING LOW-CONCENTRATION CHEMICALS AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2720075C1 |
| SUBSTRATE FOR SURFACE REINFORCED RANSCATTERING SPECTROSCOPY | 2021 |
|
RU2763861C1 |
| METHOD FOR DETECTING THE GLASS TRANSITION TEMPERATURE OF NANOSCALE POLYMER MATERIALS AND A THERMO-PLASMONIC HEATER FOR IMPLEMENTING THE METHOD | 2021 |
|
RU2771440C1 |
| METHOD FOR DETERMINING PROTEINS USING GIANT RAMAN SCATTERING USING CRYOSOLS OF PLASMON NANOPARTICLES | 2019 |
|
RU2717160C1 |
| SENSOR ELEMENT FOR ADDITIONAL SELECTIVE AMPLIFICATION OF SIGNAL OF GIANT RAMAN SCATTERING OF LIGHT | 2019 |
|
RU2709411C1 |
