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2 468 022

(13)

(51)

IPC

C07D403/06(2006-01-01)

C07D403/14(2006-01-01)

A61K31/404(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2010152560/04, 2009-05-25

(24)

Start date

2009-05-25

(22)

Actual filing date

2009-05-25

(45)

Published

2012-11-27

(72)

Inventor

Juan' ChzhehdunChzhan Sjaomin'Van KhuboChzhu Sjuehjan'Sjuj KhuntszjanFu KhojSun Vehj

(73)

Holder

Shankhaj Instit'Jut Of Farmas'Jutikal IndastriTszjansu Chiataj Tjan'Tsin Farmas'Jutikal Ko., Ltd.

DIHYDROINDOLONE DERIVATIVES Russian patent published in 2012 - IPC C07D403/06 C07D403/14 A61K31/404 A61P35/00 A61P37/00

Abstract RU 2468022 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel dihydroindolone derivatives of formula I or its pharmaceutically acceptable salts: Formula I, where values of R¹-R⁹,R¹⁶,R¹⁷,n1,n2,n3, m, are given in 1 of the formula. Described are methods of obtaining compounds.

EFFECT: compounds demonstrate anti-tumour activity, which makes it possible to use them in pharmaceutical compositions for treatment and/or prevention of diseases, associated with protein tyrosine kinases in organism, in particular for treatment and/or prevention of tumours and diseases, associated with proliferation of fibroblasts.

13 cl, 1 dwg, 5 tbl, 37 ex

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RU 2 468 022 C2

Authors

Juan' Chzhehdun

Chzhan Sjaomin'

Van Khubo

Chzhu Sjuehjan'

Sjuj Khuntszjan

Fu Khoj

Sun Vehj

Dates

2012-11-27—Published

2009-05-25—Filed