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(19)

(11)

2 337 059

(13)

(51)

IPC

C01B23/00(2006-01-01)

A61B5/55(2006-01-01)

A61K49/18(2006-01-01)

A61K51/00(2006-01-01)

(21) (22)

Application

2005109267/15, 2003-10-24

(24)

Start date

2003-10-24

(22)

Actual filing date

2003-10-24

(45)

Published

2008-10-27

(72)

Inventor

Ardenk'Er-Larsen Jan-KhenrikKhansson LennartJokhannesson KhaukurServin Rol'FVistrand Lars-Jeran

(73)

Holder

Dzhi-I Kheltker As

METHOD OF PREPARATION OF HYPERPOLARISED Xe Russian patent published in 2008 - IPC C01B23/00 A61B5/55 A61K49/18 A61K51/00

Abstract RU 2337059 C2

FIELD: chemistry.

SUBSTANCE: claimed invention relates to method of preparation of hyperpolarised ¹²⁹Xe and to method of preparation of contrast agent, applied in magnet-resonance visualisation of human or animal body. Method includes preparation of mixture of xenon at least one solvent or mixture of solvents, which represent one-chain alcohols or glycols, and/or possess good lipophilic properties, and free radical. Hyperpolarisation of said mixture is carried out according to method of dynamic nuclear polarisation in order to obtain hyperpolarised ¹²⁹Xe. Further separation of xenon from other mixture components is carried out. Presence of solvent enhances resulting polarisation. ¹²⁹Xe remains in hyperpolarised state during period long enough to obtain MP-images with higher contrast range.

EFFECT: method improvement.

10 cl, 10 ex

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RU 2 337 059 C2

Authors

Ardenk'Er-Larsen Jan-Khenrik

Khansson Lennart

Jokhannesson Khaukur

Servin Rol'F

Vistrand Lars-Jeran

Dates

2008-10-27—Published

2003-10-24—Filed