DERIVATIVES OF SUBSTITUTED DIHYDROPYRANOINDOLE-3,4-DIONE AS INHIBITORS OF PLASMINOGENE ACTIVATOR INHIBITOR-1 (PAI-1) Russian patent published in 2008 - IPC C07D491/52 C07D209/22 A61K31/407 A61P7/02 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted of dihydropyranoindole-3,4-dione of formula I and formula II: where X stands for H, R₁ stands for H, phenyl, benzyl, cycles of said phenyl and benzyl can be substituted with 1-3 substituents, selected independently on each other from group, which includes halogen, C₁-C₆-alkyl, C₁-C₆-perfluoroalkyl, -O-C₁-C₆-perfluoroalkyl, C₁-C₆-alkoxygroup; where R₂ stands for H, -OH; R3 stands for H, phenyl, benzyl, benzyloxygroup, cycles of these groups can be optionally substituted with 1-3 substituents, selected independently on each other from group including phenyl, halogen, C₁-C₆-alkyl, C₁-C₆-perfluoroalkyl, -O-C₁-C₆-perfluoroalkyl, C₁-C₆-alkoxygroup, pharmaceutically acceptable salts of said compounds. Compounds demonstrate activity of inhibiting plasminogene activator inhibitor (PAI-1), which allows using them for production of medication for treatment of pathological states resulting from fibrinolytic disorders.

EFFECT: obtaining compounds, demonstrating activity in inhibiting plasminogene activator inhibitor which allows using them in pharmacology.

23 cl, 1 dwg, 1 tbl, 13 ex