OESTROGEN RECEPTOR MODULATING COMPOUNDS Russian patent published in 2024 - IPC C07D313/08 C07D333/64 C07C215/48 C07D409/12 C07D487/04 C07D209/12 C07D209/30 A61K31/404 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds which are oestrogen receptor modulators. Disclosed is a compound of formula I', in which: B is nitrogen or carbon; D is carbon; A is a condensed ring system selected from a group consisting of: , , , and ; each R_e is independently selected from hydrogen, OH or where two adjacent R_e together form: ; each R_h is hydrogen; R_g is hydrogen, C₁-C₃-alkyl, C₁-C₃-fluoroalkyl, fluorine, chlorine or bromine; each R_a is independently selected from: H, C₁-C₃-alkyl, C₁-C₃-fluoroalkyl, phenyl (optionally substituted with 1 to 3 groups selected from fluorine, chlorine, C₁-C₃-alkyl, CN, C₁-C₃-alkyl, OH), OC_1-3 alkyl, fluorine and chlorine; X is O, CH₂ or a bond when B is carbon, or CH₂ or a bond when B is nitrogen; Y and Z are each CR_f; U and V are each CR_a; each R_f is H; and W is -CHR'-CHR'-NH-C₁-C₄-alkyl, -CHR'-CHR'-NH-C₁-C₄-fluoroalkyl, -CHR'-CHR'-NH-C₃-C₆-cycloalkyl, -CHR'-CHR'-NH-C₁-C₄-alkyl-C₃-C₆-cycloalkyl, alkyl or fluoroalkyl; where each R' independently represents H or C₁-C₃-alkyl; or a pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical composition which contains the compounds described herein, and the use of such oestrogen receptor modulators for treating diseases or conditions, particularly cancer, which are mediated or dependent on oestrogen receptors.

EFFECT: disclosed compounds modify the effects of endogenous oestrogens acting through the ER, and/or trigger ER degradation, and are applicable as agents for treating or preventing diseases or conditions, in which the actions of oestrogens and/or oestrogen receptors are involved in the aetiology or pathology of the disease or condition or contribute to at least one symptom of the disease or condition, and where such actions of oestrogen and/or oestrogen receptors are undesirable.

30 cl, 1 tbl