1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS Russian patent published in 2018 - IPC C07D213/89 C07D401/12 C07D407/12 C07D417/12 C07D213/61 A61K31/44 A61K31/4427 A61K31/5377 A61K31/496 A61P11/00 A61P37/08 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (I), N-oxides thereof on a pyridine ring and pharmaceutically acceptable salts thereof: (I), where: R₁ and R₂ are different or identical and are independently selected from the group consisting of: linear (C₁-C₆)-alkyl optionally substituted with one substituent selected from (C₃-C₇)-cycloalkyl; (C₁-C₆)-haloalkyl; (C₃-C₇)-cycloalkyl; R₃ is H or represents one or two substituents independently selected from halogen atoms; Z represents a group (CH₂)_m, where m is 0; A is a phenyl ring optionally substituted by one substituent R₄, which is selected from the group consisting of: linear (C₁-C₆)-alkyl substituted with one morpholinyl; branched (C₁-C₆)-alkyl optionally substituted by one (C₃-C₇)-cycloalkyl; (C₁-C₆)-haloalkyl; (C₁-C₆)-alkylthio; a halogen atom; and OR₇, where R₇ is selected from the group consisting of H; (C₁-C₁₀)-alkyl optionally substituted by a radical selected from (C₃-C₇)-cycloalkyl, morpholinyl, phenyl and pyridinyl; and (C₁-C₁₀)-alkyl substituted with one OH group; (C₁-C₆)-haloalkyl; (C₃-C₇)-cycloalkyl; W is selected from the group consisting of: -NR₉SO₂R₁₀, -CH₂NR₁₃SO₂R₁₄, -SO₂NR₁₅R₁₆, -NHSO₂R₁₇, -OSO₂R₁₈, -NHCOR₂₆, where R₉, R₁₀, R₁₃, R₁₄, R₁₅, R₁₆, R₁₇, R₁₈, R₂₆ are defined in the claims. Invention also relates to a pharmaceutical composition having PDE4 inhibitory activity based on compounds of formula (I), to an apparatus comprising the composition.

EFFECT: technical result is obtaining novel compounds and pharmaceutical compositions based thereon, that can be used in medicine for the treatment of an allergic disease or respiratory diseases such as atopic dermatitis, urticaria, allergic rhinitis, asthma and COPD.

14 cl, 22 tbl, 37 ex