TRISUBSTITUTED UREA AS CYTOKINE INHIBITORS Russian patent published in 2008 - IPC C07D239/48 C07D405/12 A61K31/506 A61P29/00 

FIELD: chemistry.

SUBSTANCE: in general formula , R is unsubstituted or substituted with -OH, C_1-4alkyl or -O-C_1-4alkyl, straight or branched alkyl C₁-C₄; R¹ has formula -(L)_x-R³; R³ is a fragment, chosen from a group consisting of substituted or unsubstituted phenyls, where the substitute is chosen from C_1-4alkyl, -O-C_1-4alkyl, -S-C_1-4alkyl or fluorine; R² has formula -(L¹)_y-R⁴; R⁴ is a fragment, chosen from a group consisting of i) hydrogen atom; ii) substituted with -OH, -O-C_1-4alkyl or phenyl or unsubstituted straight or branched hydrocarbyls C₁-C₁₀, where the hydrocarbyl is C_1-6alkyl; L and L¹ are bridge fragments -NR⁵-; each of the fragments R⁵ is a hydrogen atom, straight or branched alkyl C₁-C₄; indices x and y can independently assume values 0 and 1.

EFFECT: compounds can be used for curing diseases, mediated by activity of phlogistic cytokines, such as arthritis.

10 cl, 4 dwg, 3 tbl, 200 ex