FIELD: medicine; phthisiology.
SUBSTANCE: define specific mutations in Codonum 315 genes katG with PCR method with use of two external primers for a fragment 669-1103 and the internal return allelespecific primer 3-which corresponds to 2nd basis in Codonum 315 katG AGC and at amplification of a fragment of DNA in length 435 pn and absence of amplification of a fragment of DNA in length 292 pn, estimate presence of strains with mutation ACC and the ASA in the specified Codonum, steady tolerant to isoniazidum.
EFFECT: sensitivity increase.
3 ex, 2 dwg
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