PREPARATION OF HETEROLOGOUS ANTIRABIC IMMUNOGLOBULIN FOR INTRAVENOUS BOTH INTRAMUSCULAR INTRODUCTION AND METHOD FOR ITS OBTAINING Russian patent published in 2008 - IPC A61K39/205 A61K39/395 A61K35/16 

FIELD: medicine, pharmacology.

SUBSTANCE: invention concerns biotechnology, namely manufacture of medical biological preparations. It is developed a virus-safe method of obtaining of a heterological antirabic immunoglobulin from a high-avid heterological antirabic Serum using a capril-alcohol method with peptic treatment which allows obtaining a high cleaning heterological antirabic immunoglobulin for intravenous and intramuscular administration. Thus as initial raw materials use a high-avid antirabic Serum obtained from immunization of animals-producers by the cleared virus of furiousness, grown up on culture of cells Vero or PSH. The content of γ- globulene fraction in a preparation makes not less than 90%, molecular weight distribution: units no more than 1.0%, diabodies and monomers less than 10.0%, F(ab)₂ - fragments not less than 84.0%, Fab - and Fc - fragments less than 5.0%, low anticomplementary activity, specific activity not less than 150 ME/ml. An osmolarity of a ready preparation is within 250-350 mosm/kg.

EFFECT: obtaining of high cleaning heterological antirabic immunoglobulin, stable at storage and transportation.

10 cl, 3 ex, 3 tbl