PHARMACEUTICAL COMPOSITION FOR PASSIVE RABIES IMMUNIZATION, PHARMACEUTICAL KIT, PHARMACEUTICAL KIT APPLICATION METHOD Russian patent published in 2018 - IPC A61K39/42 A61P31/12 

Abstract RU 2661028 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to immunology, and can be used to produce a pharmaceutical kit for passive rabies immunization. Pharmaceutical kit placed in an acceptable package comprises: 1) a pharmaceutical composition comprising virus neutralizing anti-rabies single-domain antibodies in an effective amount and a pharmaceutically acceptable buffer solution up to 1 ml, wherein the virus neutralizing anti-rabies single-domain antibodies have an amino acid sequence SEQ ID NO.1; wherein an effective dose of virus neutralizing anti-rabies single-domain antibodies is a dose of not less than 150 ME activity, in lyophilized form; 2) a pharmaceutical composition comprising recombinant pseudo-adenovirus particles carrying a gene of virus neutralizing anti-rabies single-domain antibodies in an effective amount, a pharmaceutically acceptable buffer solution up to 1 ml; recombinant pseudo-adenovirus particles carrying a gene for virus neutralizing anti-rabies single-domain antibodies have a nucleotide sequence of a genetic insert SEQ ID NO.3, and an effective dose of recombinant pseudo-adenovirus particles carrying a gene of virus neutralizing anti-rabies single-domain antibodies is at least 5×108 PFU in 1 ml of a pharmaceutically acceptable solvent; 3) instructions for the administration of this pharmaceutical kit. Group of inventions also relates to the use of a pharmaceutical kit for passive rabies immunization.

EFFECT: use of this group of inventions provides emergency prevention of rabies through passive immunization by using the produced pharmaceutical compositions, action of which begins with 6 hours of administration and lasts up to 7 days.

2 cl, 12 ex, 4 tbl, 6 dwg

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RU 2 661 028 C2

Authors

Shmarov Maksim Mikhajlovich

Tillib Sergej Vladimirovich

Tutykhina Irina Leonidovna

Rutovskaya Marina Vladimirovna

Alekseeva Svetlana Viktorovna

Ivanova Tatyana Ilinichna

Naroditskij Boris Savelevich

Gintsburg Aleksandr Leonidovich

Dates

2018-07-11Published

2016-11-11Filed