PARTIAL AND FULL AGONISTS OF ADENOSINE RECEPTORS A Russian patent published in 2008 - IPC C07H19/167 A61K31/70 A61P9/06 A61P9/10 A61P9/00 A61P3/10 

FIELD: chemistry.

SUBSTANCE: in compound of formula (I): , R¹ represents C_1-4-alkoxy C_3-6cycloalkyl optionally substituted with atom of halogen, hydroxyl, trifluoromethyl, optionally substituted with halogen atom 5-6-member heterocyclyl, in which heteroatoms are selected from oxygen, optionally substituted with halogen atoms phenyl or optionally substituted with halogen atoms 5-6-member heteroaryl, in which heteroatoms are selected from nitrogen and/or sulfur; R² represents hydrogen or trifluoromethyl; R³ represents hydrogen, optionally substituted with atom of halogen, C_3-6cycloalkyl, optionally substituted with atom of halogen, trifluoromethyl, C_1-4-alkyl phenyl, optionally substituted with atom of halogen, trifluoromethyl, C_1-4-alkoxy heterocyclyl, which has in ring 1-2 heteroatoms, selected from nitrogen, oxygen or sulfur, or optionally substituted with C_1-4-alkyl 5-6-member heterocyclyl, which has in ring 1-2 heteroatoms, selected from nitrogen or oxygen, R⁴ and R⁵ independently represent hydrogen; X represents covalent bond or lower alkylene; X¹ represents covalent bond or lower alkylene, Y represents covalent bond or lower alkylene, optionally substituted with hydroxy or cycloalkyl; and Z represents -C=C-, -R⁶C=CR⁷- or -CHR⁶CHR⁷-, where R⁶ and R⁷ in each position represent hydrogen or lower alkyl.

EFFECT: antilipolytic effect of compounds.

30 cl, 7 dwg, 31 ex