AGONISTS OF ADENOSINE A3-RECEPTORS Russian patent published in 2007 - IPC C07H19/16 A61K31/70 A61P35/00

Abstract RU 2298557 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): , wherein R¹ represents lower alkyl or lower alkyl substituted with phenyl; X represents a covalent bond; R² represents compound of the formula: R⁴-Z-Y-C≡C-, pyrazolyl substituted with phenyl, or pyrazolyl substituted with heteroaryl wherein Y represents alkylene; Z represents oxygen atom; R⁴ represents phenyl substituted with halogen atom or (lower)-alkoxy-group comprising 1-3 carbon atoms; R³ represents hydroxymethyl group. Also, invention relates to a method for synthesis of compounds of the formula (I) and to a pharmaceutical composition possessing effect of agonist of adenosine A3-receptors. Invention provides synthesis of novel biologically active compounds and pharmaceutical compositions based on thereof possessing effect of agonist of adenosine A3-receptors.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

24 cl, 3 tbl, 18 ex

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RU 2 298 557 C2

Authors

Ehlzein Ehlfatikh

Palle Venkata

Varkhedkar Vaibkhav

Zablotski Dzheff

Dates

2007-05-10—Published

2002-08-06—Filed