FLUORINE AND TRIFLUORALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA-AMYLOID FORMATION AND THEIR DERIVATIVES Russian patent published in 2008 - IPC C07D333/34 A61K31/381 A61P25/28 

FIELD: chemistry, pharmacology.

SUBSTANCE: claimed invention relates to fluorine and trifluoralkyl-containing heterocyclic sulfonamides of general formula I , where T - CHO, COR₈ and C(OH)R₁R₂; R₁ and R₂ -hydrogen, C_1-6alkyl; R₃ -hydrogen; R₄ - (CF₃)_nalkyl, (CF₃)_nalkylphenyl, and (F)_ncycloalkyl; N equals 1-2; R₅ - hydrogen, halogen, dien, condensed with Y, when Y stands for C, and dien, condensed with Y, when Y stands for C and substituted with halogen; W, Y and Z - C, CR₆ and N, on condition that at least one of W or Y, or Z must be C; R₆ -hydrogen halogen or C_1-6alkyl; X - S and NR₇; R₇ - C_1-6alkyl; and R₈ - C_1-6alkyl. Also described are method of obtaining compounds I, pharmaceutical composition and application of compounds, intermediate compounds, used in synthesis.

EFFECT: obtaining compounds which can be used to inhibit beta-amyloid formation and for treatment of Alzheimer's disease.

48 cl, 5 tbl, 42 ex