MONO-SODIUM SALT 5-[[(2,3-DIFLUOROPHENYL)METHYL]THIO]-7-[[2-HYDROXY-1-(HYDROXYMETHYL)-1-METHYETHYL]AMINO]-THIAZOLE[4,5-d]PYRIMIDINE-2(3H)-ON AS MODULATOR OF ACTIVENESS OF CHEMOKINE RECEPTORS, ITS APPLICATIONS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2008 - IPC C07D513/04 A61K31/429 A61P37/02

Abstract RU 2342389 C2

FIELD: chemistry; pharmacology.

SUBSTANCE: present invention relates to mono-sodium salt 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]thiazole[4,5-d]pyrimidine-2(3H)-on as a modulator of the activeness of chemokine receptors, method of obtaining it and pharmaceutical composition on its basis, and also its application in production of medicinal agents.

EFFECT: obtaining compounds, which can find application in treatment of diseases mediated by chemokine receptors, such as asthma, allergic rhinitis, COPD (chronic obstructive pulmonary disease), inflammatory bowel disease, osteoarthritis, and rheumatoid arthritis.

10 cl, 2 ex

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RU 2 342 389 C2

Authors

Bonnert Rodzher Viktor

Dates

2008-12-27—Published

2003-09-16—Filed