NEW NON-STEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS OF THEIR ADMINISTRATION Russian patent published in 2008 - IPC C07H17/08 C07H17/00 A61K31/7048 A61P29/00 

FIELD: chemistry; pharmacology.

SUBSTANCE: present invention relates to new non-steroidal anti-inflammatory compounds represented with the formula I: , where M is a macrolide subunit of the formula , D is a non-steroidal subunit, obtained from a non-steroidal anti-inflammatory drug, L is a connecting group with the formula X¹-(CH₂)_m-Q-(CH₂)_n-X², or their pharmaceutically permissible salts or separate diastereoisomer. Apart from that, this invention relates to the method of obtaining compounds of the formula I (versions), to the pharmaceutical composition on the basis of the compounds of formula I or their pharmaceutically permissible salts and also to the administration of formula I or their pharmaceutically permissible salts to obtain medicine (versions). The values of the substitutes R¹-R⁶, A, B, E, U, Y, Z, W, S¹, M, D, X¹, X², Q, m, are shown in the formula of the device.

EFFECT: obtaining new non-steroidal anti-inflammatory compounds.

11 cl, 1 tbl, 7 dwg, 23 ex