HYBRIDISATION OF HETEROOLIGOMER MYCOBACTERIAL ANTIGENS Russian patent published in 2019 - IPC C07K14/35 C12N15/11 C12N15/63 C12N5/10 A61K39/04 A61P31/04 A61P31/06 

FIELD: biotechnology.

SUBSTANCE: described is a poxvirus-based expression vector which contains a nucleic acid molecule(s) coding a hybrid of heteroligomer mycobacterial antigens ESAT6 and CFP10 and preferably a hybrid comprising the amino acid sequence presented in SEQ ID NO: 1. Disclosed is a host cell for producing a poxvirus-based vector according to any of the claims. 1–13, comprising a poxvirus-based vector according to any of claims. 1–13. Described is a composition for treating or preventing a mycobacterial infection or any disease and pathological condition caused or associated with such a mycobacterial infection, containing an effective amount of a vector according to any of the claims. 1–13 or a host cell according to claim 14 or any combination thereof.

EFFECT: present invention serves to induce or stimulate an immune response in order to provide a protective response against a mycobacterial infection or any disease caused or associated with a mycobacterial infection.

26 cl, 2 dwg, 4 tbl, 4 ex