FIELD: chemistry; pharmacology.
SUBSTANCE: present invention relates to biotechnology. The described molecules of antibodies, having specificity in relation to human CD22, containing at least one CDR obtained from mouse monoclonal antibodies. Also discovered is a CDR-grafted antibody, in which at least one of the CDR is a modified CDR. The DNA sequence of the coding strand of the antibody molecule is described. Vectors are offered which contain the described DNA sequence, transformed host-cells, containing the offered vectors. The administration of antibody molecules during the treatment of diseases, mediated by cells expressing CD22 has been discovered.
EFFECT: obtaining antibodies, which posses a high affinity to CD22 and immunogenic inferiority to humans.
28 cl, 16 dwg, 2 ex
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