FIELD: chemistry.
SUBSTANCE: invention concerns new 8-aza-bicyclo[3.2.1]octane derivatives of formula I 
or any its isomer or mixed isomers, or their pharmaceutically acceptable salt, where Ra represents hydrogen; X represents -O-; Rb represents aryl or heteroaryl group chosen from phenyl, naphthyl, pyridyl, quinolinyl, isoquinolinyl or quinazolinyl substituted with one or two substitutes independently chosen from group including: halogeno, trifluoromethyl, trifluoromethoxy, cyano, hydroxy and alkoxy provided that compound is not 3-(3-trifluoromethylphenoxy)-8-azabcyclo[3.2.1]octane, 3-(4-trifluoromethylphenoxy)-8-azabcyclo[3.2.1]octane, 3-(2-bromphenoxy)-8-azabcyclo[3.2.1]octane, 3-(4-chlorophenoxy)-8-azabcyclo[3.2.1]octane or 3-(4-fluorophenoxy)-8-azabcyclo[3.2.1]octane. Besides invention refers to pharmaceutical composition and application thereof.
EFFECT: production of new biologically active compounds characterised with monoamine recapture inhibiting activity.
6 cl, 1 ex, 1 tbl
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