NOVEL CHROMAN-2-ONE DERIVATIVES AND USE THEREOF AS MONOAMINE NEUROMEDIATOR REUPTAKE INHIBITORS Russian patent published in 2010 - IPC C07D451/06 A61K31/137 A61K31/428 A61K31/46 A61P25/16 A61P25/24 A61P25/28 A61P25/30 

Abstract RU 2382040 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula or to any isomer thereof, or mixture of isomers thereof, or pharmaceutically acceptable salt thereof, where R1 represents hydrogen or alkyl; R2 and R3 together form -(CH2)2-, and R2' and R3' represent hydrogen, m equals 1; n equals 1; X represents -O-; and Q represents chroman-2-on-7-yl, which is possibly substituted with one or more substitutes independently selected from a group consisting of halogen, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl. The invention also relates to a pharmaceutical composition, as well as to use of chemical compound in any of paragraphs 1-4.

EFFECT: obtaining novel biologically active compounds having monoamine neuromediator reuptake inhibitory activity.

8 cl, 10 ex, 1 tbl

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RU 2 382 040 C2

Authors

Peters Dan

Ol'Sen Gunnar M.

Sheel'-Krjuger Jorgen

Niel'Sen Ehl'Sebet Ehstergord

Dates

2010-02-20Published

2005-09-28Filed