METHOD OF OBTAINING DERIVATIVES OF 8H-THIENO[2,3-b]INDOLE Russian patent published in 2009 - IPC C07D495/04 

Abstract RU 2345082 C1

FIELD: chemistry.

SUBSTANCE: claimed invention relates to method of obtaining derivatives of 8-thieno[2,3-b]indole of general formula I and can be used for obtaining biologically active substances. Method is characterised by the fact that derivatives of 2-alkyl-5-(2-isothiocyanoaryl)furanes are mixed in 1,2-dichloroethane in presence of aluminium chloride with molar ratio of initial substance and aluminium chloride 1:1÷1:2 at temperature from room temperature to temperature of 1,2-dichloroethane boiling for from 30 min to 48 hours. I a-e, Ia R1 = H, R2 = CH3, b R1 = H, R2 = CH2CH3, c R1 = CI, R2 = CH3, d R1 = CH3, R2 = CH3, e R1 = OCH3, R2 = CH3.

EFFECT: extension of series of potentially biologically active derivatives of the said agent.

1 cl, 6 ex, 3 tbl

Similar patents RU2345082C1

Title Year Author Number
4-SUBSTITUTED-3-(1-ALKYL-2-CHLORO-1H-INDOL-3-YL)FURAN-2,5-DIONES, SYNTHESIS METHOD THEREOF AND USE IN PHOTOCHEMICAL GENERATION OF STABLE FLUORESCENT COMPOUNDS AND 4,5-SUBSTITUTED-6-ALKYL-1H-FURO[3,4-c]CARBAZOLE-1,3(6H)-DIONES, SYNTHESIS METHOD THEREOF AND USE AS FLUOROPHORES 2009
  • Rybalkin Vladimir Petrovich
  • Metelitsa Anatolij Viktorovich
  • Levchenko Pavel Viktorovich
  • Shepelenko Evgenij Nikolaevich
  • Makarova Nadezhda Ivanovna
  • Bren' Vladimir Aleksandrovich
  • Minkin Vladimir Isaakovich
RU2396267C1
3-(5-ALKOXY-1,2-DIMETHYL-1H-INDOLE-3-YL)-4-[(1E)-ALK-1-ENYL]FURAN-2,5-DIONES AND THEIR USING AS FLUORESCENT PHOTOCHROMES 2006
  • Metelitsa Anatolij Viktorovich
  • Rybalkin Vladimir Petrovich
  • Levchenko Pavel Viktorovich
  • Makarova Nadezhda Ivanovna
  • Bren' Vladimir Aleksandrovich
  • Minkin Vladimir Isaakovich
RU2314304C1
QUATERNARY AMMONIUM COMPOUNDS BASED ON PENTAERYTHRITOL AND PYRIDOXINE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY 2023
  • Shtyrlin Iurii Grigorevich
  • Sapozhnikov Sergei Vitalevich
  • Shtyrlin Nikita Valerevich
  • Biktimirova Alina Sergeevna
  • Bulatova Elena Sergeevna
  • Agafonova Mariia Nikolaevna
RU2811203C1
8-ALKYL-2-(THIOPHEN-2-YL)-8H-THIOPHENE[2,3-b]INDOLE SUBSTITUTED 2-CYANOACRYLIC ACIDS, METHOD FOR PRODUCTION THEREOF AND NOVEL INTERMEDIATE COMPOUNDS USED THEREFOR 2014
  • Charushin Valerij Nikolaevich
  • Rusinov Gennadij Leonidovich
  • Irgashev Roman Akhmetovich
  • Karmatskij Arsenij Andreevich
RU2565072C1
DERIVATIVES OF PYRIDOPYRIMIDINES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 2002
  • Chen' Jan' Dzheffri
  • Dann Dzhejms Patrik
  • Goldshtejn Dejvid Majkl
  • Shtal' Kristof Martin
RU2269527C2
2-R-6-R-5-ARYL-PYRROLE[3,4-c]CARBAZOLE-1,3(2H,6H)-DIONE SYNTHESIS METHOD 2009
  • Levchenko Pavel Viktorovich
  • Shepelenko Evgenij Nikolaevich
  • Makarova Nadezhda Ivanovna
  • Rybalkin Vladimir Petrovich
  • Metelitsa Anatolij Viktorovich
  • Tolpygin Ivan Evgen'Evich
  • Dubonosov Aleksandr Dmitrievich
  • Bren' Vladimir Aleksandrovich
  • Minkin Vladimir Isaakovich
RU2404983C1
PYRIDOPYRROLIZINE AND PYRIDOINDOLIZINE DERIVATIVES 2003
  • Leblan Iv
  • Djufren Klod
  • Roj Patrik
RU2342386C2
METHOD OF PRODUCING INDOLIZINO[7,6-b]INDOLE DERIVATIVES 2010
  • Pilipenko Arkadij Sergeevich
  • Uchuskin Maksim Grigor'Evich
  • Butin Aleksandr Valerianovich
  • Trushkov Igor' Vladimirovich
RU2439073C1
1-SUBSTITUTED 3-(2-CHLORO-1H-INDOL-3-YL)-4-PHENYL-1H-PYRROLE-2,5-DIONES AND USE THEREOF IN PHOTOCHEMICAL GENERATION OF STABLE FLUORESCENT COMPOUNDS AND 2,8-SUBSTITUTED BENZO[a]PYRROLO[3,4-c]CARBAZOLE-1,3-(2H,8H)-DIONES AND USE THEREOF AS FLUOROPHORES 2009
  • Rybalkin Vladimir Petrovich
  • Shepelenko Evgenij Nikolaevich
  • Levchenko Pavel Viktorovich
  • Makarova Nadezhda Ivanovna
  • Metelitsa Anatolij Viktorovich
  • Popova Lidija Leonidovna
  • Bren' Vladimir Aleksandrovich
  • Minkin Vladimir Isaakovich
RU2402547C1
DERIVATIVES OF GLYCOSIDES OF INDOLO[2,3-A]-PYRROLO[3,4-C]CARBAZOL-5,7-DIONES ELICITING CYTOTOXIC AND ANTITUMOR ACTIVITY 2003
  • Mel'Nik S.Ja.
  • Ostrovskaja L.A.
  • Adanin V.M.
  • Bakhmedova A.A.
  • Bljukhterova N.V.
  • Vlasenkova N.K.
  • Garaeva L.D.
  • Gorjunova O.V.
  • Miniker T.D.
  • Plikhtjak I.L.
  • Rykova V.A.
  • Fomina M.M.
  • Ehktova L.V.
  • Jartseva I.V.
RU2255089C1

RU 2 345 082 C1

Authors

Butin Aleksandr Valerianovich

Tsiunchik Fatima Alekseevna

Abaev Vladimir Tajmurazovich

Dates

2009-01-27Published

2007-10-30Filed