CHIMERIC POLYPEPTIDE - GROWTH HORMONE RECEPTOR ANTAGONIST, NUCLEIC ACID, EXPRESSION VECTOR, CHIMERIC POLYPEPTIDE APPLICATION (VERSIONS), PHARMACEUTICAL COMPOSITION, CELL, METHOD OF OBTAINING CHIMERIC POLYPEPTIDE AND METHOD OF TREATMENT Russian patent published in 2009 - IPC C12N15/62 C07K14/61 C12N15/12 C12N15/18 A61K38/17 A61K38/27 A61P5/06 

FIELD: chemistry; biochemistry.

SUBSTANCE: present invention pertains to genetic engineering, more specifically to chimeric polypeptides, containing an antagonist of growth hormone receptor. The invention can be used in medicine. The binding domain of the growth hormone is modified by substituting glycine amino acid residue in position 120 and is further modified in site 1, where at least one amino acid residue is substituted, which increases affinity of the growth hormone to its binding domain on the growth hormone receptor. The amino acid residue is then conjugated with the ligand-binding domain of the growth hormone receptor, through a peptide linker.

EFFECT: obtaining a highly effective antagonist of the growth hormone receptor with longer half-life, reduced immunogenesity and nontoxicity, compared to known mutant forms.

35 cl, 16 dwg, 1 tbl