PIPERIDINE DERIVATIVE OR ITS PHARMACEUTICAL SALT Russian patent published in 2009 - IPC C07D211/16 C07D401/12 C07D413/06 C07D471/18 C07D487/08 A61K31/4545 A61K31/496 A61P25/04 

FIELD: chemistry.

SUBSTANCE: present invention pertains to a new piperidine derivative, with the following general formula (I) where R¹ - R⁴ each stands for any of the univalent groups, indicated below: R¹ stands for a hydrogen atom, halogen atom, inferior alkyl, which can be substituted with a halogen atom or OH; -O-inferior alkyl, which can be substituted with a halogen atom; -O-aryl, aryl, -C(=O)-inferior alkyl, COOH, -C(=O)-O-inferior alkyl, -C(=O)-NH₂, -C(=O)NH-inferior alkyl, -C(=O)N-(inferior alkyl)₂, OH, -O-C(=O)-inferior alkyl, NH₂, -NH-inferior alkyl, -N-(inferior alkyl)₂, NH-C(=O)- inferior alkyl, CN or NO₂; R² and R³ each stands for a hydrogen atom; and R⁴ stands for any of the univalent groups (a), (b) and (c), shown below in formula 2 where in the above indicated groups (a), (b) and (c), A stands for a pyrrolidine, piperidine, morpholine, piperizine or oxazepane ring; B stands for a pyrrolidine or piperidine ring; R⁵ and R⁸-R¹¹ can be identical or different from each other and each stands for a hydrogen atom, -C(=O)-O-inferior alkyl, cycloalkyl or tetrahydropyrane; R⁶ stands for a hydrogen atom, -C(=O)-O-inferior alkyl, OH, -inferior alkylene-OH or -C(=O)-pyridine; and R⁷ stands for a hydrogen atom. The invention also pertains to pharmaceutical salts of the piperidine derivative, as well as medicinal compositions.

EFFECT: obtaining new biologically active compounds and a medicinal composition, based on these compounds, which is a sodium channel inhibitor.

10 cl, 91 ex, 22 tbl