NEW DERIVATIVES OF 5, 7-DISUBSTITUTED [1, 3] THIAZOLO[4, 5-D] PYRIMIDINE-2(3H)-ONE Russian patent published in 2011 - IPC C07D513/04 A61K31/519 A61P25/00 A61P9/10 A61P11/06

Abstract RU 2411245 C9

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to derivatives of 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidine-2(3H)-one of formula (I) where R¹ represents CH₃ or CH₃CH₂; R² represents H, 3-CN, 2-CF₃, 2-F, 3-F, 3-CF₃, 3-CONH₂ or SO₂CH₃; R³ represents H; R⁴ represents H or CH₃; and R⁵ represents H; or, when R⁴ represents CH₃, R⁵ represents H or F; and to its pharmaceutically acceptable salts. Also, the invention refers to a pharmaceutical composition exhibiting properties of CX₃CR1 receptor antagonist containing compound (I) of formula or its pharmaceutically acceptable salt mixed with a pharmaceutically acceptable diluent or carrier.

EFFECT: enabled administration of the derivatives of 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidine-2(3H)-one as selective CX₃CR1 receptor antagonists.

13 cl, 1 tbl, 20 ex

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RU 2 411 245 C9

Authors

Nordvall' Gunnar

Rehj Kolin

Rejn Tobias

Son Dehniel

Dates

2011-02-10—Published

2006-04-03—Filed