PYRASOLE[3,4-b]PYRIDINE COMPOUNDS AND THEIR APPLICATION AS PHOSPHODIESTERASE INHIBITORS Russian patent published in 2009 - IPC C07D471/04 A61K31/437 A61P11/00 A61P25/00 A61P29/00 A61P37/00 

Abstract RU 2348633 C2

FIELD: chemistry.

SUBSTANCE: invention concerns compound of formula (I) where Ry is , or its pharmaceutically acceptable salts. These compounds have phosphodiesterase (PDE) inhibition effect, particularly for PDE-4. Additionally invention claims application of compound of the formula (I) or its pharmaceutically acceptable salt in manufacturing of medicine for treatment and/or prevention of cognitive ability depression or disorder of humans, e.g. of chronic neurological disorder, such as Alzheimer's disease.

EFFECT: enhanced efficiency of composition and treatment method.

17 cl, 21 tbl, 191 ex

Similar patents RU2348633C2

Title Year Author Number
PYRAZOLO[3,4-b]PURIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITION (VERSIONS), APPLICATION (VERSIONS), COMBINATION (VERSIONS) 2003
  • Allen Dejvid Dzhordzh
  • Kou Dajan Mehri
  • Kuk Kehrolin Mehri
  • Doul Majkl Dehnnis
  • Ehdlin Kristofer Dejvid
  • Khehmblin Dzhuli Nikol'
  • Dzhonson Martin Redpat
  • Dzhounz Pol Spenser
  • Noulz Richard Grehm
  • Mitchell Sharlott Dzhejn
  • Redgrejv Ehlison Dzhudit
  • Uord Piter
  • Lindvall Mika Kristian
RU2357967C2
SERINE/THREONINE KINASE INHIBITORS 2013
  • Blejk Dzhejms F.
  • Chikarelli Mark Jozef
  • Gerri Rustam Ferdinand
  • Gaudino Dzhon
  • Grina Dzhonas
  • Moreno Devid A.
  • Mor Peter Dzh.
  • Ren Li
  • Shvarts Dzhejkob
  • Chen Khuejfen
  • Robardzh Kirk
  • Chzhou Ajkhe
RU2650501C2
AZAINDAZOLE OR DIAZAINDAZOLE DERIVATIVES AS MEDICINE 2012
  • Kalun El Bakhir
  • Bedzhegelal Karim
  • Rabo Remi
  • Kryuzinski Anna
  • Shmitt Filipp
  • Peres Mishel
  • Raje Nikolya
RU2600976C2
METHODS OF OBTAINING AND PURIFICATION OF HETEROARYL COMPOUNDS 2010
  • Kharris Roj L.
  • Sapienza Dzhon
  • Shevlin Graziehlla
  • Papa Patrik
  • Li Brenden Dzhingsi
  • Pakard Garrik
  • Chzhao Tszintszin
  • Dzhokil Patrik Ehntoni
  • Mortensen Debora
  • Riggs Dzhennifer
  • Gamboa Khuan Antonio
  • Bosham Mehri Dzhordzh
  • Krejlejn Mehtt'Ju Majkl
  • Kotare Mokhit Atul
  • Perren-Ninkovich Sofi
  • Paj Filip
  • Leong Uill'Jam Vehj-Khva
  • Ehl'Sner Jan
  • Choudkhuri Anusuja
RU2557242C2
PIPERIDINE DERIVATIVES 2011
  • Baumann Karlkhajnts
  • Flor Aleksandr
  • Getshi Ehrvin
  • Grin Ljuk
  • Zholidon Siniz
  • Knust Khenner
  • Limberg An'Ja
  • Luehbbers Tomas
  • Tomas Ehndrju
RU2554353C2
NOVEL DERIVATIVE OF PURINYLPYRIDINYLAMINO-2,4-DIFLUOROPHENYLSULPHONAMIDE, ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF ITS OBTAINING AND PHARMACEUTICAL COMPOSITION, WHICH HAS INHIBITION ACTIVITY WITH RESPECT TO RAF-KINASE, CONTAINING CLAIMED COMPOUND AS ACTIVE INGREDIENT 2011
  • Shim Eun Kiong
  • Kim Nam Doo
  • Shim Tae Bo
  • Kim Seung Jong
RU2550038C2
mTOR KINASE INHIBITORS FOR ONCOLOGICAL INDICATIONS AND DISEASES METABOLICALLY BOUND TO mTOR/PI3K/AKT 2009
  • Ehl'Sner Jan
  • Kharris Roj L.
  • Li Brehnden
  • Mortensen Debora
  • Pakard Garrik
  • Papa Patrik
  • Perren-Ninkovich Sofi
  • Riggs Dzhennifer
  • Sankar Sabita
  • Sapienza Dzhon
  • Shevlin Graziehlla
  • Terani Lida
  • Sjuj Vehjmin
  • Chzhao Tszintszin
  • Parnes Dzhejson
  • Madakamutil Lui
  • Fults Kimberli
  • Narla Rama K.
RU2546658C2
DERIVATIVES OF AZAINDASOLE OR DIAZAINDASOLE TYPE FOR PAIN TREATMENT 2013
  • Sokoloff Per
  • Kashu Frederik
RU2640046C2
SUBSTITUTED 2H-PYRANO[2,3-C]PYRIDINES, COMBINATORY AND FOCUSED LIBRARIES 2003
  • Zhuravel' Irina Aleksandrovna
  • Ivashchenko A.V.
  • Kovalenko Sergej Nikolaevich
  • Tkachenko S.E.
  • Chernykh V.P.
  • Okun' Il'Ja Matusovich
RU2261251C2
NEW COMPOUNDS FOR TREATING AMYLOID OR AMYLOID-LIKE PROTEIN ASSOCIATED DISEASES 2007
  • Freshtl' Vol'Fgang
  • Srinivasachari Nampalli
  • Lomann Sofi
  • Lopes-Deber Marija-Pilar
  • Mus Andreas
  • Pil'Gren-Bosh Marija
RU2469026C2

RU 2 348 633 C2

Authors

Allen Dejvid Dzhordzh

Kou Dajan Mehri

Kuk Karolin Mehri

Kuper Ehntoni Uil'Jam Dzhejms

Doul Majkl Dehnnis

Ehdlin Kristofer Dejvid

Khehmblin Dzhuli Nikol'

Dzhonson Martin Redpat

Dzhounz Pol Spenser

Lindvall Mika Kristian

Mitchell Sharlotta Dzhejn

Rehdgrehjv Ehlison Dzhudit

Dates

2009-03-10Published

2003-12-19Filed