AMINOALCOXYINDOLES, AS LIGANDS OF 5-NT6 RECEPTOR, FOR TREATMENT OF CNS DISEASES Russian patent published in 2009 - IPC C07D209/30 C07D403/12 C07D401/12 C07D498/06 A61K31/404 A61P25/28 

FIELD: medicine.

SUBSTANCE: in the formula I or it pharmaceutically comprehensible salt: m it is peer 3; n it is peer from 0 to 2; all R¹ independently mean H; R² means aryl, unessentially replaced 1-2 assistants chosen from group, including halogen, and C₁-C₁₂alcoxy; R³ means H, C₁-C₁₂alkyl; p it is peer 2 or 3; R⁵, R⁶, R⁷ and R⁸ independently mean H, C₁-C₁₂alkyl, or one of R⁵ and R⁶ together with one of R⁷ and R⁸ and the atoms located between them can form a 4-7-termed heterocyclic ring, or R⁷ and R⁸ together with atom of nitrogen to which they are attached, can form a 5-7-termed heterocyclic ring; or one of R⁵ and R⁶ together with R³ and the atoms located between them can form a 5-7-termed heterocyclic ring. Bonds I possess selective opposing activity in the relation of 5-NT6 receptor.

EFFECT: possibility to use bond in a pharmaceutical composition for treatment of CNS and gastroenteric tract.

16 cl, 8 dwg, 2 tbl, 10 ex