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2 294 932

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(51)

IPC

C07D401/02(2006-01-01)

C07D403/02(2006-01-01)

A61K31/496(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2003136731/04, 2002-05-29

(24)

Start date

2002-05-29

(22)

Actual filing date

2002-05-29

(45)

Published

2007-03-10

(72)

Inventor

Behrd Kolin CharlzKlark Robin DuglasFisher Lorens EhmersonKharris Iii Ral'F N'JuRepke Dejvid Brjus

(73)

Holder

F.Khoffmann-Lja Rosh Ag

INDOLE DERIVATIVES SHOWING AFFINITY TO 5-HT RECEPTORS Russian patent published in 2007 - IPC C07D401/02 C07D403/02 A61K31/496 A61P25/00

Abstract RU 2294932 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel derivatives of indole of the general formula (I): wherein R¹ means -S(O)_0-2-A wherein A means phenyl optionally substituted with one or some groups or some groups chosen from (lower)-alkyl, (lower)-alkoxy-group, halogen atom, (lower)-halogenalkyl, (lower)-alkylsulfonyl or (lower)-halogenalkylsulfonyl, naphthyl, pyridinyl or benzothiazolyl; R² means hydrogen atom, (C₁-C₆)-alkyl; R³ means hydrogen atom, (C₁-C₆)-alkyl; R⁴ means hydrogen atom, or one radical among R⁵, R⁶ or R⁷ means group of the general formula (B) wherein W means group -CH- or nitrogen atom, and others mean independently hydrogen atom; R⁸ means hydrogen atom, (C₁-C₁₀)-alkyl; R⁹ and R¹⁰ mean independently hydrogen atom, or their pharmaceutically acceptable salts. Compounds of the formula (I) possess affinity to 5-HT₆ receptors that allows their using in pharmaceutical composition.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

20 cl, 14 ex

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RU 2 294 932 C2

Authors

Behrd Kolin Charlz

Klark Robin Duglas

Fisher Lorens Ehmerson

Kharris Iii Ral'F N'Ju

Repke Dejvid Brjus

Dates

2007-03-10—Published

2002-05-29—Filed