BENZOXAZINE DERIVATIVES AND THEIR APPLICATION Russian patent published in 2009 - IPC C07D265/36 C07D413/04 A61K31/538 A61P25/28 A61P1/00 

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds of general formula (I) or to its pharmaceutically acceptable salts or to it solvates, where m is equal 0 to 3, X stands for N, Y stands for -SO₂-, each R¹ independently stands for halogen, C₁-C₁₂alkyl, halogen(C₁-C₁₂)alkyl, hydroxy(C₁-C₆)alkyl, R² stands for aryl or heteroaryl which represents monocyclic radical containing 5 to 12 atoms in a cycle, including one, two or three nitrogen heteroatoms in a cycle optionally substituted with halogen or cyano, each R³ and R⁴ independently stands for C₁-C₁₂alkyl, or R³ and R⁴ together with carbon atom whereto they are attached, form the cyclic group containing 3-6 atoms in a cycle, and each R⁵, R⁶, R⁷, R⁸ and R⁹ stands for hydrogen. Besides, the invention concerns the pharmaceutical composition.

EFFECT: preparation of the new biologically active compounds with antagonistic action to 5-NT6 receptor.

15 cl, 6 ex, 2 tbl