FIELD: chemistry, pharmacology.
SUBSTANCE: invention refers to new compounds of formula I 
, where A stands for =C(R4)-, D stands for =C(R5)-, E stands for =C(R6)-, or one of A, D and E stands for =N-, L stands for =N- or =C(H)-, M stands for =C(R7)-, when L stands for =N-, or M stands for when L stands for -C(H)-, Q stands for CF3 or CHF2, R1 stands for -CN, unsubstituted pyridinyl, pyridinyl, substituted (C1-C4)-alkyl or (C1-C4alkanole, or stands for related pyridine N-oxide, R2 stands for hydrogen, R3 stands for hydrogen, R4 stands for hydrogen, halogen, unsubstituted (C1-C4)alkyl or fluorine substituted (C1-C4)alkyl, unsubstituted (C1-C4)alkoxy group or fluorine substituted (C1-C4)alkoxy group, unsubstituted (C3-C6)cycloalkyl or fluorine substituted (C3-C6)-cycloalkyl, R5 stands for hydrogen, halogen, unsubstituted (C1-C4)alkyl or fluorine substituted (C1-C4)alkyl, unsubstituted (C3-C6)cycloalkyl or fluorine substituted (C3-C6)cycloalkyl, R6 stands for hydrogen or halogen, and R7 stands for hydrogen, unsubstituted (C1-C4)alkyl or cyanogen group substituted (C1-C4)alkyl, unsubstituted (C3-C6)cycloalkyl or cyanogen group substituted (C3-C6)cycloalkyl provided when A stands for =C(R4)-, D stands for =C(H)-, E stands for =C(H)-, L stands for =N-, R1 stands for -CN, R2 stands for hydrogen, R3 stands for hydrogen, and (a) M stands for =C(H)-, R4 is not hydrogen, chlorine or methoxygroup; or (b) M stands for =C(CH3)-, R4 is not hydrogen, and to its pharmaceutically acceptable acid-additive salts. Besides, the invention concerns pharmaceutical compositions.
EFFECT: production of the new biologically active compounds with antagonistic activity to metabotropic glutamate receptor.
29 cl, 9.5 ex
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