SUBSTITUTED QUINOLONES HAVING ANTIVIRAL ACTIVITY, SYNTHESIS METHOD THEREOF, MEDICINAL AGENT AND USE THEREOF IN FIGHTING VIRAL INFECTIONS Russian patent published in 2011 - IPC C07D401/04 C07D498/04 C07D471/10 C07D498/10 C07D401/14 A61K31/4709 A61P31/22 

FIELD: chemistry.

SUBSTANCE: present invention relates to organic chemistry and specifically to novel derivatives of quinolone or one pharmaceutically acceptable salts thereof, solvates thereof or solvates of salts thereof, having general formula I , in which R¹ denotes fluorine, R³ denotes halogen, a hydroxy group or a C₁-C₄-alkoxy group, R⁴ denotes C₁-C₆-alkyl or C₃-C₈-cycloalkyl, where the alkyl can contain 1-3 substitutes, and the substitutes are independently selected from a group comprising halogen or trifluoromethyl, and where the cycloalkyl can contain 1-3 halogen atoms as substitutes, or R³ and R⁴ together with atoms to which they are bonded form a ring with a group of formula , in which * indicates a site for bonding with a carbon atom, and # indicates a site for bonding with a nitrogen atom, R⁷ and R⁸ independently denote halogen, trifluoromethyl, a monofluoromethoxy group, a difluoromethoxy group, a trifluoromethoxy group, C₁-C₃-alkyl or C₁-C₃-alkoxy group, and R⁹ denotes hydrogen, halogen or C₁-C₃-alkyl, or R⁸ denotes a trifluoromethoxy group, and R⁷ and R⁹ denote hydrogen, R¹⁰ denotes a group of formula or , in which * indicates a site for bonding with a carbon atom, R² is bonded in position 3 or 4 and denotes a hydroxy group, hydroxycarbonyl, aminocarbonyl, C₁-C₄-alkyl, C₁-C₄-alkoxycarbonyl, C₃-C₆-cycloalkylcarbonyl or optionally hydroxy-substituted C₁-C₆-alkylaminocarbonyl, where the alkyl is substituted with one substitute and the substitute is selected from a group comprising a hydroxy group, hydroxycarbonyl, aminocarbonyl, C₁-C₄-alkoxycarbonyl and 2-oxopyrrolidin-1-yl, R⁵ and R⁶ are independently bonded in positions 3, 4 or 5 and independently denote hydrogen, hydroxy group, methyl or ethyl, and Y denotes a methylene group or an oxygen atom. The invention also relates to methods of producing a compound of formula I, a medicinal agent based on the compound of formula I, use of the compound of formula I and a method of fighting viral infections.

EFFECT: novel substituted quinolone derivatives which are useful in treating viral diseases are obtained.

11 cl, 1 tbl, 69 ex