FIELD: medicine.
SUBSTANCE: claimed invention relates to field of molecular biology, virology and medicine. Claimed is application of adenovirus for manufacturing medication for tumor treatment. Said virus is replication-deficient in cells which do not contain YB-1 in nucleus and encodes oncogenic protein E1A, which transactivates at least one viral gene from group including E1B55kDa, E4orf6, E4orf6 and E3ADP.
EFFECT: invention can be used for treating tumors demonstrating resistance to many cytostatic medications.
19 cl, 19 dwg, 13 ex
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