NEW ESTERS OF HYDROXIMIC ACIDS AND THEIR PHARMACEUTICAL APPLICATION Russian patent published in 2009 - IPC C07C259/10 C07D213/61 C07D261/04 C07D413/12 C07D213/38 C07D213/84 C07D407/12 C07D417/12 C07D213/53 C07D233/22 C07D409/12 A61K31/165 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds of general formula (I) where R₁ stands for hydrogen or linear, branched, saturated or unsaturated hydrocarbon radical; D stands for nitrogen atom or C-R₂; E stands for nitrogen atom or C-R₃; F stands for nitrogen atom or C-R₄; G stands for nitrogen atom or C-R₅; R₂, R₃, R₄ and R₅ are identical or different and individually represent hydrogen, halogen, alkoxy, linear or branched, saturated or unsaturated hydrocarbon radical; W stands for oxygen atom; X stands for radical of formula radical -(CH₂)_k-C(O)-(CH₂)_m-, -(CH₂)_n- or -(CH₂)_r-O-(CH₂)_s-, where k, m, r and s are equal to integers 0 to 6, and n is equal to an integer 1 to 6. Said radicals are optionally substituted with one or more substitutes independently chosen from the group consisting of R7; Y stands for radical of formula radical -(CH₂)_i-NH-C(O)-(CH₂)_j-, -(CH₂)_n-, -(CH₂)_r-O-(CH₂)_s-, -(CH₂)_t-NH-(CH₂)_u-, where i, j, n, r, s, t and u are equal to integers 0 to 6. Said radicals are optionally substituted C_1-3alkyl, or C_1-3alkyl-C_1-3alkylsulphonylamino; radicals R₇, B, R₈, A, R₉ are as it is presented in the patent claim. The invention also describes the pharmaceutical composition possessing inhibitory activity of receptor tyrosine kinase to KDR receptor including described compounds.

EFFECT: compounds possess inhibitory activity of receptor tyrosine kinase to KDR receptor and can be effective in therapy of the diseases associated uncontrolled angiogenesis.

29 cl, 746 ex, 6 tbl