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2 535 203

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IPC

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

C07D405/14(2006-01-01)

C07D413/14(2006-01-01)

A61K31/496(2006-01-01)

A61K31/5377(2006-01-01)

A61P35/00(2006-01-01)

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Application

2012127790/04, 2010-06-01

(24)

Start date

2010-06-01

(22)

Actual filing date

2010-06-01

(45)

Published

2014-12-10

(72)

Inventor

Branko MilanDaj JudzhiaDin KhunDouehrti Dzhordzh A.Ehlmor Stiven V.Khasvol'D LizaKheksamer LauraKanzer AaronMantej Robert A.Makklellan Uill'Jam Dzh.Park Chang Kh.Park Cheol-MinPetros Ehndrju M.Sun SjaokhunSauehrs Ehndrju Dzh.Sallivan Dzherard M.Tao Chzhi-FuVan Gari T.Van LehVan SiluUehndt Majkl D.Khansen Todd M.

(73)

Holder

Ehbbvi Ink.

APOPTOSIS-INDUCING AGENTS FOR TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Russian patent published in 2014 - IPC C07D401/12 C07D403/12 C07D405/14 C07D413/14 A61K31/496 A61K31/5377 A61P35/00

Abstract RU 2535203 C2

FIELD: medicine, pharmaceitics.

SUBSTANCE: invention relates to particular derivatives of N-(phenylsulphonyl)benzamide, given in i.1 of the invention formula. The invention also relates to a pharmaceutical composition, possessing an inhibiting activity with respect to anti-apoptotic proteins Bcl-2, containing an effective quantity of one of the said compounds or a therapeutically acceptable salt of such a compound.

EFFECT: N-(phenylsulphonyl)benzamide derivatives as inhibitors of the anti-apoptotic proteins Bcl-2.

2 cl, 2 tbl, 458 ex

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RU 2 535 203 C2

Authors

Branko Milan

Daj Judzhia

Din Khun

Douehrti Dzhordzh A.

Ehlmor Stiven V.

Khasvol'D Liza

Kheksamer Laura

Kanzer Aaron

Mantej Robert A.

Makklellan Uill'Jam Dzh.

Park Chang Kh.

Park Cheol-Min

Petros Ehndrju M.

Sun Sjaokhun

Sauehrs Ehndrju Dzh.

Sallivan Dzherard M.

Tao Chzhi-Fu

Van Gari T.

Van Leh

Van Silu

Uehndt Majkl D.

Khansen Todd M.

Dates

2014-12-10—Published

2010-06-01—Filed