1, 2-DIHYDROCYCLOBUTANEDIONE DERIVATIVES AS NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS Russian patent published in 2014 - IPC C07D213/74 C07D401/12 C07D413/12 C07F9/44 A61K31/5355 A61K31/4409 A61K31/5377 A61K31/444 A61K31/55 A61K31/4439 A61K31/496 A61K31/4725 A61K31/675 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compound of formula (I) , where A is selected from -C(=O)-, -S(=O)₂-, and -P(=O)(R⁵)-, where R5 is selected from C_1-6-alkyl, C_1-6-alkoxy and hydroxy; B is selected from single bond, -O-, and -C(=O)-NR⁶-, where R⁶ is selected from hydrogen; D is selected from single bond, -O-, and -NR⁹, where R⁷, R⁸ and R⁹ are independently selected from hydrogen; m equals integer number 0-12 and n equals integer number 0-12, where the sum m+n equals 1-20; p equals integer number 0-2; R¹ is selected from optionally substituted heteroaryl, where heteroaryl represents aromatic carbocyclic ring, where one carbon atom is substituted with heteroatom; R² is selected from hydrogen, optionally substituted C_1-12-alkyl, and substituents are selected from phenyl, morpholine, halogen and pyridine; C_3-12-cycloalkyl, -[CH₂CH₂O]_1-10-C_1-6-alkyl); and R³ is selected from optionally substituted C_1-12-alkyl, and substituents are selected from morpholine, phenyl, dialkylamine and C_3-12-cycloalkyl, optionally substituted with halogen aryl; or R² and R³ together with adjacent atoms form optionally substituted with alkylcarbonyl or alkyl N-containing heterocyclic or heteroaromatic ring; each of R⁴ and R^4* independently represents hydrogen; and their pharmaceutically acceptable salts, as well as to application of said compounds for treatment of diseases/states, induced by increased level of nicotinamide phosphoribosyltransferase (NAmPRTase).

EFFECT: obtaining novel compounds.

21 cl, 1 dwg, 2 tbl, 83 ex