FIELD: medicine.
SUBSTANCE: there are offered recombinant protein molecule M2E-HBC, and virus-like particles formed of such molecules. The recombinant virus-like particle based on nuclear antigen of hepatitis B virus represents surface polypeptides of outer domain M2 of avian influenza virus protein. The produced virus-like particles are characterised with high immunogenicity. There is also disclosed vaccine for the infection caused by avian influenza virus, including such virus-like particles as an active agent.
EFFECT: preparations are active to various strains of avian influenza virus and can be considered as a candidate for universal avian influenza virus type A vaccine.
7 cl, 8 dwg, 4 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT SWINE INFLUENZA VIRUS H1N1 VACCINE AND METHOD FOR PREPARING IT | 2010 |
|
RU2451027C2 |
| RECOMBINANT VIRAL VECTOR AND EXPRESSION SYSTEM IN PLANT CELLS OF HYBRID PROTEIN CONTAINING EXTRACELLULAR DOMAIN OF PROTEIN M2 OF INFLUENZA VIRUS ATTACHED TO CORE ANTIGEN OF HEPATITIS B VIRUS | 2010 |
|
RU2460796C2 |
| RECOMBINANT ANTI-INFLUENZA VACCINE WITH WIDE RANGE OF PROTECTION AND METHOD FOR ITS PREPARATION | 2017 |
|
RU2757013C2 |
| CROSS-REACTIVE RECOMBINANT HUMAN INFLUENZA A VIRUS VACCINE | 2020 |
|
RU2742336C1 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| UNIVERSAL ANTI-INFECTIOUS VACCINE | 2015 |
|
RU2618918C2 |
| STRAIN OF HYBRID CULTIVATED MURINE CELLS Mus Musculus - 4F11 PRODUCING MONOCLONAL ANTIBODY RESPONDER WITH HEMAGGLUTININ PROTEIN OF HIGH-PATHOGEN STRAIN virus A/duck/Novosibirsk/56/05 H5N1 | 2008 |
|
RU2384617C1 |
| STRAIN OF HYBRID CULTIVATED MURINE CELLS Mus Musculus-6F3 PRODUCING MONOCLONAL ANTIBODY NONTOLERANT TO HEMAGGLUTININ PROTEIN OF HIGH-PATHOGEN STRAIN virus A/duck/Novosibirsk/56/05 H5N1 | 2008 |
|
RU2385929C1 |
| ANTIVIRAL SIMILAR MINI-ANTIBODY, NUCLEOTIDE SEQUENCE, EXPRESSING RECOMBINANT VIRAL VECTOR, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR THERAPY OF INFLUENZA TYPE A | 2013 |
|
RU2536956C1 |
| ANTI-FLU NANOANTIBODY, RECOMBINANT VIRAL VECTORS AND PHARMACEUTICAL COMPOSITIONS FOR PROPHYLAXIS AND THERAPY OF A-TYPE FLU | 2011 |
|
RU2502745C2 |
