FIELD: biotechnology.
SUBSTANCE: invention relates to immunology and protein engineering. Described is a cross-reactive recombinant human influenza virus A vaccine comprising a recombinant HBc-4M2eh protein which has the amino acid sequence SEQ ID NO 6, in amount of 20 to 90 mcg and sodium deoxyribonucleate adjuvant in amount of 1,000 to 10,000 mcg, as well as phosphate-buffer solution (PBS), pH 7.2–7.4.
EFFECT: invention provides anti-influenza vaccine with a wide range of protection ("universal") effective for controlling a pandemic and an influenza epidemic.
12 cl, 25 tbl, 3 ex, 5 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT SWINE INFLUENZA VIRUS H1N1 VACCINE AND METHOD FOR PREPARING IT | 2010 |
|
RU2451027C2 |
| UNIVERSAL AVIAN INFLUENZA VIRUS VACCINE | 2007 |
|
RU2358981C2 |
| RECOMBINANT ANTI-INFLUENZA VACCINE WITH WIDE RANGE OF PROTECTION AND METHOD FOR ITS PREPARATION | 2017 |
|
RU2757013C2 |
| UNIVERSAL ANTI-INFECTIOUS VACCINE | 2015 |
|
RU2618918C2 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| IMMUNOGENIC COMPOSITION, CONTAINING FOREIGN ANTIGENS ON SURFACE OF SPHERICAL CARRIERS, OBTAINED BY THERMAL DENATURATION OF SPIRAL VIRUSES | 2010 |
|
RU2440140C1 |
| VIRIONS AND VIRUS-LIKE PARTICLES OF ALTERNANTHERA MOSAIC VIRUS AS AMPLIFIERS OF IMMUNE RESPONSE | 2015 |
|
RU2639491C2 |
| IMMUNOGENIC COMPOSITIONS AND METHODS | 2008 |
|
RU2468034C2 |
| PASSAGE VECTOR AND VACCINE FOR TUBERCULOSIS | 2007 |
|
RU2453603C2 |
| FUNCTIONAL INFLUENZA VIRUS-LIKE PARTICLES (VLPs) | 2006 |
|
RU2483751C2 |
